Unraveling Your Genome. Individualizing Radiation Therapy
 

Unraveling Your Genome. Individualizing Radiation Therapy. 

Cvergenx, Inc. is a genomic informatics company that provides decision-support to radiation oncologists to assist in radiation treatment planning. This novel technology provides radiation oncologists the first opportunity to personalize and optimize radiation treatment planning and therapy within existing standards of care. 

 
 
 
DNA Magnified.jpg

Technology

 
 

Cvergenx has developed an informatics-based approach to radiation treatment planning that enables radiation oncologists to personalize and optimize radiation therapy. 

The company’s Precision Genomic Radiation Therapy platform (pGRT™) takes a mathematical, rather than empirical, approach to the integration of genomics into radiation treatment and planning. This unique application of medical mathematics is central to the Cvergenx patented Radiosensitivity Index (RSI) and Genomic Adjusted Radiation Dose (GARD). Combined, these parameters provide the first opportunity to adapt radiation treatment and dose to improve outcomes on a patient-by-patient basis.

 

We are now in the process of demonstrating how patients can benefit by integrating biological information into radiotherapy treatment plans to optimize dose on an individualized basis.

 

 
 
 
 
 

The sequencing of the human genome has revealed that cancer is not a single disease but multiple diseases that are inherently different at the genetic level. This realization has led to the era of precision medicine. 

 
 
 
Microarray Analysis.jpg

News & Publications

 
 

"We are focused on delivering a genomic framework for personalized medicine using biological information to inform the radiation treatment parameters. This technology allows us to predict which patients benefit from radiation more than others allowing for the personalization of radiation therapy." 
— Javier Torres-Roca, MD

 

PRESS RELEASES >

Moffitt Cancer Center & Cvergenx Partner to Personalize Radiation Therapy

August 9, 2017

Tampa, FL — Moffitt Cancer Center and Cvergenx announced a new research partnership that aims to revolutionize radiation therapy. The goal of the Future of Radiation Therapy (FORT) project is to create a framework for using a patient’s genetic information to provide a personalized radiation treatment plan. READ FULL PRESS RELEASE 


A Tailored Approach to Cancer Treatment

Tampa Bay Times, August 18, 2017

Tampa, FL — Treatment at Moffitt Cancer Center has been more precise since doctors and researchers there began using targeted drug therapies nearly a decade ago. And soon they plan to expand on that approach, known as personalized medicine, to include radiation therapy. READ FULL PRESS RELEASE 


Cvergenx, Inc. Brings Radiation Oncology into the Era of Individualized Medicine

January 4th, 2017

Tampa, FL — In an endeavor to bring radiation oncology into the era of individualized medicine, Cvergenx, Inc. today reaffirmed its plans to commercialize the first genomics-driven approach to precision radiation therapy. This advance, recently recognized by The Lancet Oncology, one the most widely read and well respected peer-reviewed oncology journals in the world today, was echoed in an editorial commentary in the same publication. READ FULL PRESS RELEASE 

 

MEDIA >

Genomic Modeling
for Radiation Dosage

The Lancet Oncology podcast, February 1, 2017

Javier Torres-Roca, MD and Louis B. Harrison, MD discuss genome-based modeling and its uses in calculating the appropriate radiation dosage.

 
 

PUBLICATIONS >


The Future of Personalized Radiotherapy for Head and Neck Cancer

The Lancet Oncology, Volume 18, Number 5, May 2017


Radiation Oncology Enters the Era of Individualized Medicine

The Lancet Oncology, Volume 18, Number 2, February 2017


Personalizing Radiation Dose

International Journal of Radiation Oncology, Volume 98, Number 5, August 2017



Personalized Medicine in Radiation Oncology

International Journal of Radiation Oncology, Volume 92, Number 4, April 2015


Genome-based Modeling-A Significant Step Toward the Future of Personalized Radiation Therapy

Translational Cancer Research, Volume 6 Supplement 2, March 2017


 

 
 
 

 

The vision and mission of Cvergenx is to bring precision medicine to radiation oncology by enabling clinicians to personalize and optimize radiation therapy dose to match an individual’s biology and genetic differences. 

 
 
 
 
Binary Analysis_2.jpg

Our Leadership

 

Cvergenx is led by an experienced team of highly trained clinicians, biostatisticians and business professionals with a deep understanding of radiation oncology, genomics, bioinformatics and technology commercialization.

 
RFV_2.jpg

Raymond F. Vennare

Raymond F. Vennare (Chairman & CEO) is an accomplished senior executive and biotechnology entrepreneur with a long history of founding, launching and leading companies ranging bioinformatics, diagnostics and therapeutic drug delivery to FDA-cleared medical devices. In addition to advising nationally ranked universities, philanthropic organizations and multi-national publicly traded companies, Raymond is past co-founder and CEO of Thermal Therapeutic Systems, President and Chief Executive Officer of ImmunoSite, Senior Vice President and Chief Information Officer of TissueInformatics and President of VSinteractive.

JTR_Headshot.jpg

Javier F. Torres-Roca, MD

Javier F. Torres-Roca, MD (Co-founder & Chief Medical Advisor) is Director of Clinical Research in the Department of Radiation Oncology at Moffitt Cancer Center and clinical faculty with a sub-specialty in urological and cutaneous malignancies. Javier earned his medical degree from the University of Puerto Rico followed by post-doctoral training in immunology and molecular biology with Nobel Laureate Professor Luc Montagnier (Institute Pasteur) and Drs. Irving Weismann and Leonard Herzenberg (Stanford). He completed his clinical training in radiation oncology at the University of California and is an ABR board certified radiation oncologist.

Steven Eschrich.jpg

Steven A. Eschrich, PhD

Steven A. Eschrich, PhD (Co-founder & CSO) is Senior Member at the H. Lee Moffitt Cancer Center and Research Institute in the Department of Biostatistics and Bioinformatics, Scientific Director of the Moffitt Cancer Center Cancer Informatics Core Facility and Associate Professor of Oncologic Sciences at the University of South Florida. Dr. Eschrich received his Ph.D. from the University of South Florida with an emphasis on developing scalable machine learning algorithms for bioinformatics applications including extensive experience in gene expression microarray analysis in translational cancer research.

 
KOKALES_JOHN_MD.JPG

John G. Kokales, MD

John G. Kokales, MD, (Board Director) is a former practicing physician, Senior Medical Director for Medicare and Medical Director for UPMC Health Plan. John chaired the Pharmacy & Therapeutics Committee, co-chaired the Quality Committee for the CMI physician network and chaired the Clinical Pathways Committee at Shadyside Hospital. He is past Member of the Physicians Advisory Committee of the CMI, the Critical Clinical Information Task Force for Cerner Electronic medical record implementation, the Physician Advisory Committee Cerner Hospital implementation and Institutional Review Board at UPMC Shadyside.

BUSH_PAMELA.jpg

Pamela A. Bush, PhD/MBA

Pamela A. Bush, PhD/MBA (Board Director) is the former Director of Corporate Business Development at Eli Lilly & Company where she was lead negotiator for term sheets and contracts to in-license and out-license strategic assets. Before becoming Director or Corporate Business Development, Pamela served as manager in R&D Finance at Lilly and served as Director of Investment Programs for the Pittsburgh Life Sciences Greenhouse in Pittsburgh, PA. Pamela holds a PhD from Carnegie Mellon University, College of Science, and MBA from the Carnegie Mellon University, Tepper School of Business.

 
 
 
 

The Radio Sensitivity Index (RSI) was developed as an objective measure of tumor intrinsic radiosensitivity and Genomic Adjusted Radiation Dose (GARD) was developed to optimize radiation therapy dose based upon the biological differences across tumors.

 
 
 
Genetic Mutation.jpg

Contact Us

 

If you would like more information about the company, our expertise or the pGRT technology platform, please don’t hesitate to contact us directly. We respect your privacy and treat all electronic communication as personal, proprietary and confidential.

Name *
Name